Aim of the present study was to analyze whether rutin has the potential to inhibit or attenuate ethanol withdrawal induced handling convulsion in mice or not. Male mice received an ethanol containing (1.6%, 3.6%, 6.3%) liquid diet for 10 days and were tested for withdrawal signs and symptoms at 2, 4, 6, 8, 10 h after termination of the diet on day 11. The anticonvulsant activity of rutin (50, 75 and 100 mg/kg, i.p.) was evaluated in mice models of pentylenetetrazole. In the PTZ-induced seizure model, rutin treatment was given where acute treatment at low dose showed protection against convulsion while treatment at high dose of rutin showed complete absence of convulsions.
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